Annoviant™ Awarded $2.99 Million NIH Grant to Advance TxGuard™ Pulmonary-Valved Conduit for Pediatric Heart Disease

Atlanta, April 16, 2024 – Annoviant, Inc., a pioneering company with a breakthrough TxGuard ^TM  technology platform for soft-tissue healing, currently focused on cardiovascular field, proudly announces receipt of a $2.99 million grant (SBIR Phase 2b) from the National Institutes of Health (NIH). This grant aims to propel the development and commercialization of its revolutionary TxGuardpulmonary valved conduit. Building upon the Phase II NIH Grant secured in 2021, this funding represents a significant step forward in Annoviant’s mission to transform the landscape of pediatric cardiac care.

Annoviant’s patented TxGuardstands at the forefront of technological innovation in conduit replacements for treating congenital heart disease (CHD), the most prevalent birth defect globally and a leading cause of birth-related mortality. CHD encompasses a spectrum of abnormalities that disrupt blood flow to and from the heart, affecting approximately 40,000 newborns annually in the US and 1.35 million worldwide. With an estimated 2.9 million CHD patients in the US alone, the need for advanced solutions is paramount.

Addressing critical shortcomings observed in current commercial devices, TxGuardoffers unparalleled clinical advantages, notably its resistance to calcification, thrombosis, infection, and the host cell integration. This cutting-edge technology heralds a new era in pediatric cardiac interventions, providing durable pulmonary valved grafts that adapt and regenerate alongside patients, minimizing the need for multiple re-operations over their lifetimes.

Pediatric patients with CHD often undergo multiple cardiovascular surgeries throughout their lives, with associated costs totaling billions for the US healthcare industry. TxGuardoffers a transformative solution to this ongoing challenge, promising extended durability and reduced healthcare burden for patients and providers alike.

Dr. Naren Vyavahare, Ph.D., Annoviant’s CTO, and Co-Founder, commented, “Pediatric CHD patients require medical devices that can evolve with them into adulthood. After fifteen years of dedicated research, we have developed TxGuardtechnology to address this critical need, resisting thrombosis and calcification while promoting host cell integration and remodeling. With NIH Phase IIb funding, we look forward to further refining pulmonary valved conduits for the benefit of CHD patients.”

Founded in 2018, Annoviantis a pioneering healthcare innovation company committed to the development of transformative medical devices aimed at enhancing and saving lives. Driven by the personal experiences of its co-founders, Annoviant is fueled by an unwavering dedication to positively impact the lives and treatment outcomes of congenital heart disease (CHD) patients. At the heart of Annoviant’s mission is TxGuard, a patented breakthrough innovation designed to heal and adapt alongside patients battling life-threatening congenital heart disease and other soft tissue applications. This portfolio of patented breakthrough devices addresses numerous clinical challenges, offering the potential to significantly reduce healthcare costs by obviating the need for repetitive surgeries. Annoviant actively collaborates with a diverse network, including leading research institutions and industry partners nationwide, to advance its innovative solutions. For further details, please visit  Annoviant.com.